Loh Laboratory

We employ human pluripotent stem cells to reconstitute and understand developmental biology. We are mapping the branching lineage choices through which human pluripotent stem cells differentiate into over two dozen different types of cells. Guided by this developmental roadmap, we have created nearly-pure batches of human blood, blood vessel, bone, liver, and other cells from pluripotent stem cells. This is opening new opportunities for regenerative medicine and is helping us to explore fundamental mechanisms of developmental biology.