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The Loh Laboratory employs stem cells to reconstitute and understand human developmental biology. By applying our knowledge of development, we intend to generate pure populations of desired human tissue progenitors and create a platform for stem cell-driven regenerative medicine.

Embryonic stem cells have been touted for their therapeutic value for years, but their potential for regenerative medicine has yet to be fully realized. To the present day, there have been difficulties in precisely guiding embryonic stem cells to differentiate into desired human cell-types in a dish.

To meet this challenge, we have delineated a comprehensive roadmap that describes how embryonic stem cells can develop into a broad spectrum of different human cell-types through a sequence of pairwise lineage choices. This roadmap has enabled the production of nearly-pure populations of human tissue progenitors, providing new opportunities for regenerative medicine and to interrogate early human tissue development. As for the latter, we are interested in understanding the molecular basis of multilineage competence and defining stepwise molecular changes during cell-fate transitions.

Science

As developmental and stem cell biologists, we aspire to understand how tissue progenitors are specified and how tissues incipiently take shape and form during embryonic development.

Research
Publications

About us

We are part of the Institute for Stem Cell Biology & Regenerative Medicine and the Department of Developmental Biology, Stanford University School of Medicine. We are looking for graduate students or postdoctoral fellows to join us!

Affiliations

Contact us

Loh Laboratory, 265 Campus Drive
Lorry I. Lokey Stem Cell Research Building, Rm G3105
Stanford University School of Medicine
Stanford, CA 94305 USA

  • Kyle Loh (Faculty, kyleloh@stanford.edu)
  • Laura Dunkin-Hubby (Coordinator, lhubby@stanford.edu)
  • Office: 650-736-8530 | Lab: 650-724-1308
  • News

    In collaboration with Philip Beachy, Joseph Liao and Lay Teng Ang, the laboratory was recently awarded a CIRM Discovery grant to generate human bladder progenitors from pluripotent stem cells.
    Feb 20 2018 | Cell Reports
    Together with Lay Teng Ang and colleagues, we mapped how human liver cells develop through six consecutive steps. Human embryonic stem cell-derived liver cells could regenerate human liver cells in a mouse model of liver failure and improve survival.  
    In collaboration with Lay Teng Ang and Irv Weissman, the laboratory was recently awarded a CIRM Discovery grant to generate human liver progenitors from pluripotent stem cells.
    Nov 6 2017 | Nature Methods
    During embryonic lung development, Sox9+ lung progenitors generate both major parts of the lung (airways and alveoli). Together with Massimo Nichane and colleagues, we developed a method to expand Sox9+ lung progenitors in vitro.
    Oct 10 2017 | Cell Reports
    How do stem cells divide and differentiate? Using live imaging, together with Kate Brown and Roel Nusse, we found that incipiently-differentiating human embryonic stem cells tend to divide to generate daughter cells which adopt asymmetric lineage outcomes.
    The laboratory was recently awarded the NIH Director's Early Independence Award, under the High Risk, High Reward Research Program.
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