Publications
Research articles
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells
Fowler JL*, Zheng SL*, Nguyen A**, Chen A**, Xiong X, Chai T, Chen JY, Karigane D, Banuelos AM, Niizuma K, Kayamori K, Nishimura T, Cromer MK, Gonzalez-Perez D, Mason C, Liu DD, Yilmaz L, Miquerol L, Porteus MH, Luca VC, Majeti R, Nakauchi H, Red-Horse K, Weissman IL, Ang LT†, Loh KM† (2024). Developmental Cell, advance online publication.
Liver size is predetermined in the neonate by adding lobules at the periphery
Azizoglu DB, Perez K, Zheng SL, Rahman S, Rim EY, Anbarchian T, Fish M, Loh KM, Red-Horse K, Nusse R (2023). bioRxiv.
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype
Shah PP*, Keough KC*, Gjoni K*, Santini GT, Abdill RJ, Wickramasinghe NM, Dundes CE, Karnay A, Chen A, Salomon REA, Walsh PJ, Nguyen SC, Whalen S, Joyce EF, Loh KM, Dubois N, Pollard KS†, Jain R† (2023). Genome Biology 24: 16.
Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling
Gonzalez-Perez D, Das S, Antfolk D, Ahsan HS, Medina E, Dundes CE, Jokhai RT, Egan ED, Blacklow SC, Loh KM, Rodriguez PC, Luca VC (2022). Nature Chemical Biology, advance online publication.
Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses
Ang LT*, Nguyen A*, Liu KJ*, Chen A**, Xiong XC**, Curtis M, Martin RM, Raftry BC, Ng CY, Vogel U, Lander A, Lesch BJ, Fowler JL, Holman AR, Chai T, Vijayakumar S, Suchy FP, Nishimura T, Bhadury J, Porteus MH, Nakauchi H, Cheung C, George SC, Red-Horse K, Prescott JB† & Loh KM† (2022). Cell 185: 2523-2541.
See also: artery and vein single-cell RNA-seq web portal and artery and vein single-cell RNA-seq matrix files
Dach1 Extends Artery Networks and Protects Against Cardiac Injury
Raftrey B, Williams M, Rios Coronado PE, Fan X, Chang AH, Zhao M, Roth R, Trimm E, Racelis R, D'Amato G, Phansalkar R, Nguyen A, Chai T, Gonzalez KM, Zhang Y, Ang LT, Loh KM, Bernstein D, Red-Horse K (2021). Circulation Research 129:702-716.
Genome edited orthogonal safeguards to improve the safety of human pluripotent stem cell-based therapies
Martin RM*, Fowler JL*, Cromer MK, Lesch BJ, Ponce E, Uchida N, Wiebking V, Nishimura T, Porteus MH†, Loh KM† (2020). Nature Communications 11: 2713.
Copy Number Variation at 16p11.2 Imparts Transcriptional Alterations in Neural Development in an hiPSC-derived Model of Corticogenesis
Roth JG*, Muench KL*, Asokan A, Mallett VM, Gai H, Verma Y, Weber S, Charlton C, Fowler JL, Loh KM, Dolmetsch RE, Palmer TD (2020). eLife 9: e58178.
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation
Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, Nakauchi H, Yamazaki S (2019). Nature 571:117-121.
Isolation and 3D expansion of multipotent Sox9+ mouse lung progenitors
Nichane M, Javed A, Sivakamasundari V, Ganesan M, Ang LT, Kraus P, Lufkin T, Loh KM†, Lim B† (2017). Nature Methods 14, 1205-1212.
Thirst-associated preoptic neurons encode an aversive motivational drive
Allen WE*, DeNardo LA*, Chen MZ*, Liu CD, Loh KM, Fenno LE, Ramakhrishnan C, Deisseroth K†, Luo L† (2017). Science 357: 1149-1155.
Inhibition of apoptosis overcomes stage-related compatibility barriers to chimera formation in mouse embryos
Masaki H, Kato-Itoh M, Umino A, Sato H, Ito K, Yanagida A, Hirabayashi M, Sasaki E, Yamaguchi T, Loh KM, Weissman IL, Nakauchi H (2016). Cell Stem Cell 19: 587-592.
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors: induction and underlying mechanisms
Hui C, Ang HYK, Farran CAEL, Li P, Fang H, Liu T, Kong SL, Chin ML, Lim EKH, Li H, Huber H, Loh KM, Loh YH, Lim B (2016). Nature Communications 7: 13396.
Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions.
Durruthy-Durruthy J, Briggs SF, Awe J, Ramathal CY, Karumbayaram S, Lee PC, Heidmann JD, Clark A, Karakikes I, Loh KM, Wu JC, Hoffman AR, Byrne J, Reijo Pera RA, Sebastiano V (2014). PLoS ONE 9: e94231.
Review and protocol articles
Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development
Loh KM & Ang LT (2024). Seminars in Cell and Developmental Biology 155(Pt C):62-75.
Bridging naïve and primed pluripotency
Dundes CD & Loh KM (2020). Nature Cell Biology 22: 513-515.
Efficient differentiation of human pluripotent stem cells into liver cells
Loh KM, Palaria A, Ang LT (2019). Journal of Visualized Experiments 148: e58975.
Evaluating the regenerative potential and functionality of human liver cells in mice
Tan AKY, Loh KM, Ang LT (2017). Differentiation 98: 25-34.
Ex uno plures: molecular designs for embryonic pluripotency
Loh KM, Lim B, Ang LT (2015). Physiological Reviews 95: 245-295.
Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?
Roberts RM, Loh KM, Amita M, Bernardo AS, Adachi K, Alexenko AP, Schust DJ, Schulz LC, Telugu BP, Ezashi T, Pedersen RA (2014). Reproduction 147: D1-D12.
Close encounters with full potential
Loh KM and Lim B (2013). Nature 502: 41-42.
Investigating the bona fide differentiation capacity of human pluripotent stem cells
Heng DJC, Loh KM, Ng HH (2012). Cell Research 22: 6-8.
A precarious balance: pluripotency factors as lineage specifiers
Loh KM and Lim B (2011). Cell Stem Cell 8: 363-9.