Publications
Genome edited orthogonal safeguards to improve the safety of human pluripotent stem cell-based therapies
Martin RM*, Fowler JL*, Cromer MK, Lesch BJ, Ponce E, Uchida N, Wiebking V, Nishimura T, Porteus MH†, Loh KM† (2020)
Nature Communications 11: 2713 PDF
Spatially controlled stem cell differentiation via morphogen gradients: a comparison of static and dynamic microfluidic platforms
Cui KW*, Engel L*, Dundes CE, Nguyen TC, Loh KM, Dunn AR (2020)
Journal of Vacuum Science & Technology A 38: 033205 PDF
Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance
George BM, Kao KS, Kwon HS, Velasco BJ, Poyser J, Chen A, Le AC, Chhabra A, Burnett CE, Cajuste D, Hoover M, Loh KM, Shizuru JA, Weissman IL (2019)
Cell Stem Cell doi: 10.1016/j.stem.2019.05.018 PDF
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation
Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, Nakauchi H, Yamazaki S (2019)
Nature doi:10.1038/s41586-019-1244-x PDF
A roadmap for human liver differentiation from pluripotent stem cells
Ang LT, Tan AKY, Autio MI, Goh SH, Choo S, Lee KL, Tan J, Pan B, Lee JJ, Lum JJ, Lim Y, Yeo K, Wong J, Oh L, Chia P, Chen A, Chen QF, Weissman IL, Loh KM†, Lim B† (2018)
Cell Reports 22, 2190-2205 PDF
Isolation and 3D expansion of multipotent Sox9+ mouse lung progenitors
Nichane M, Javed A, Sivakamasundari V, Ganesan M, Ang LT, Kraus P, Lufkin T, Loh KM†, Lim B† (2017)
Nature Methods 14, 1205-1212 PDF
Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates
Brown K*, Loh KM*, Nusse R (2017)
Cell Reports 21: 301-307 PDF
Thirst-associated preoptic neurons encode an aversive motivational drive
Allen WE*, DeNardo LA*, Chen MZ*, Liu CD, Loh KM, Fenno LE, Ramakhrishnan C, Deisseroth K†, Luo L† (2017)
Science 357: 1149-1155 PDF
Mapping the pairwise choices leading from pluripotency to human bone, heart, and other mesoderm cell types
Loh KM*, Chen A*, Koh PW, Deng T, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Ng SC, Fernhoff NB, George BM, Wernig G, Salomon RAE, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT†, Weissman IL† (2016)
Cell 166: 451-67 PDF
Link to single-cell RNA-seq data
Inhibition of apoptosis overcomes stage-related compatibility barriers to chimera formation in mouse embryos
Masaki H, Kato-Itoh M, Umino A, Sato H, Ito K, Yanagida A, Hirabayashi M, Sasaki E, Yamaguchi T, Loh KM, Weissman IL, Nakauchi H (2016)
Cell Stem Cell 19: 587-592 PDF
An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development
Koh PW*, Sinha R*, Barkal AA, Morganti RM, Chen A, Weissman IL†, Ang LT†, Kundaje A†, Loh KM† (2016)
Scientific Data 3: 160109 PDF
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors: induction and underlying mechanisms
Hui C, Ang HYK, Farran CAEL, Li P, Fang H, Liu T, Kong SL, Chin ML, Lim EKH, Li H, Huber H, Loh KM, Loh YH, Lim B (2016)
Nature Communications 7: 13396 PDF
Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
Loh KM*, Ang LT*, Zhang J**, Kumar V**, Ang J, Auyeong JQ, Lee KL, Choo SH, Lim CYY, Nichane M, Tan J, Noghabi MS, Azzola L, Ng ES, Durruthy-Durruthy J, Sebastiano V, Poellinger L, Elefanty AG, Stanley EG, Chen Q, Prabhakar S, Weissman IL, Lim B (2014)
Cell Stem Cell 14: 237-52 PDF
Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions.
Durruthy-Durruthy J, Briggs SF, Awe J, Ramathal CY, Karumbayaram S, Lee PC, Heidmann JD, Clark A, Karakikes I, Loh KM, Wu JC, Hoffman AR, Byrne J, Reijo Pera RA, Sebastiano V (2014)
PLoS ONE 9: e94231 PDF
Bridging naïve and primed pluripotency
Dundes CD & Loh KM (2020)
Nature Cell Biology: advance online publication (News & Views) PDF
A critical look: Challenges in differentiating human pluripotent stem cells into desired cell types and organoids
Fowler JL, Ang LT, Loh KM (2019)
Wiley Interdiscip Rev Dev Biol: e368 (Review) PDF
Obliterating obstacles to an odyssey
Nichane M, Loh KM (2018)
Cell Stem Cell 23: 313-15 (Preview) PDF
Evaluating the regenerative potential and functionality of human liver cells in mice
Tan AKY, Loh KM, Ang LT (2017)
Differentiation 98: 25-34 (Review) PDF
Generating spatial form and cellular diversity: Wnt signaling and the evolution of multicellular animals
Loh KM*, van Amerongen R*, Nusse R (2016)
Developmental Cell 38: 643-655 (Perspective) PDF
Ex uno plures: molecular designs for embryonic pluripotency
Loh KM, Lim B, Ang LT (2015)
Physiological Reviews 95: 245-295 (Review) PDF
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Clevers H, Loh KM, Nusse R (2014)
Science 346: 1248012 (Review) PDF
Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?
Roberts RM, Loh KM, Amita M, Bernardo AS, Adachi K, Alexenko AP, Schust DJ, Schulz LC, Telugu BP, Ezashi T, Pedersen RA (2014)
Reproduction 147: D1-D12 (Perspective) PDF
Investigating the bona fide differentiation capacity of human pluripotent stem cells
Heng DJC, Loh KM, Ng HH (2012)
Cell Research 22: 6-8 (Preview) PDF
A precarious balance: pluripotency factors as lineage specifiers
Loh KM and Lim B (2011)
Cell Stem Cell 8: 363-9 (Perspective) PDF
