Publications

Metabolically purified human stem cell-derived hepatocytes reveal distinct effects of Ebola and Lassa viruses

Prescott JB*, Liu KJ*, Lander A, Pek NMQ, Jha SK, Bokelmann M, Begur M, Koh PW, Yang H, Lim B, Red-Horse K, Weissman IL, Loh KM, Ang LT (2025). bioRxiv.

DNMT3AR882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency

Köhnke T, Karigane D, Hilgart E, Fan AC, Kayamori K, Miyauchi M, Collins CT, Suchy FP, Rangavajhula A, Feng Y, Nakauchi Y, Martinez-Montes E, Fowler JL, Loh KM, Nakauchi H, Koldobskiy MA, Feinberg AP, Majeti R (2024). bioRxiv.

TMX1, a disulfide oxidoreductase, is necessary for T cell function through regulation of CD3zeta

Chai T, Loh KM†, Weissman IL† (2024). bioRxiv.

Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells

Fowler JL*, Zheng SL*, Nguyen A**, Chen A**, Xiong X, Chai T, Chen JY, Karigane D, Banuelos AM, Niizuma K, Kayamori K, Nishimura T, Cromer MK, Gonzalez-Perez D, Mason C, Liu DD, Yilmaz L, Miquerol L, Porteus MH, Luca VC, Majeti R, Nakauchi H, Red-Horse K, Weissman IL, Ang LT†, Loh KM† (2024). Developmental Cell, advance online publication.

See also: hematopoietic differentiation single-cell RNA-seq web portal, GitHub portal, and single-cell RNA-seq .h5 files 

Liver size is predetermined in the neonate by adding lobules at the periphery

Azizoglu DB, Perez K, Zheng SL, Rahman S, Rim EY, Anbarchian T, Fish M, Loh KM, Red-Horse K, Nusse R (2023). bioRxiv.

An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

Shah PP*, Keough KC*, Gjoni K*, Santini GT, Abdill RJ, Wickramasinghe NM, Dundes CE, Karnay A, Chen A, Salomon REA, Walsh PJ, Nguyen SC, Whalen S, Joyce EF, Loh KM, Dubois N, Pollard KS†, Jain R† (2023). Genome Biology 24: 16.

Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling

Gonzalez-Perez D, Das S, Antfolk D, Ahsan HS, Medina E, Dundes CE, Jokhai RT, Egan ED, Blacklow SC, Loh KM, Rodriguez PC, Luca VC (2022). Nature Chemical Biology, advance online publication.

Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses

Ang LT*, Nguyen A*, Liu KJ*, Chen A**, Xiong XC**, Curtis M, Martin RM, Raftry BC, Ng CY, Vogel U, Lander A, Lesch BJ, Fowler JL, Holman AR, Chai T,  Vijayakumar S, Suchy FP, Nishimura T, Bhadury J, Porteus MH, Nakauchi H, Cheung C, George SC, Red-Horse K, Prescott JB† & Loh KM† (2022). Cell 185: 2523-2541.

See also: artery and vein single-cell RNA-seq web portal and artery and vein single-cell RNA-seq matrix files

Dach1 Extends Artery Networks and Protects Against Cardiac Injury

Raftrey B, Williams M, Rios Coronado PE, Fan X, Chang AH, Zhao M, Roth R, Trimm E, Racelis R, D'Amato G, Phansalkar R, Nguyen A, Chai T, Gonzalez KM, Zhang Y, Ang LT, Loh KM, Bernstein D, Red-Horse K (2021). Circulation Research 129:702-716.

Spatially controlled stem cell differentiation via morphogen gradients: a comparison of static and dynamic microfluidic platforms

Cui KW*, Engel L*, Dundes CE, Nguyen TC, Loh KM†, Dunn AR† (2020). Journal of Vacuum Science & Technology A 38: 033205.

Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance

George BM, Kao KS, Kwon HS, Velasco BJ, Poyser J, Chen A, Le AC, Chhabra A, Burnett CE, Cajuste D, Hoover M, Loh KM, Shizuru JA, Weissman IL (2019). Cell Stem Cell 25, 185-192.

A roadmap for human liver differentiation from pluripotent stem cells

Ang LT, Tan AKY, Autio MI, Goh SH, Choo S, Lee KL, Tan J, Pan B, Lee JJ, Lum JJ, Lim Y, Yeo K, Wong J, Oh L, Chia P, Chen A, Chen QF, Weissman IL, Loh KM†, Lim B† (2018). Cell Reports 22, 2190-2205.

Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates

Brown K*, Loh KM*, Nusse R (2017). Cell Reports 21: 301-307.

Mapping the pairwise choices leading from pluripotency to human bone, heart, and other mesoderm cell types

Loh KM*, Chen A*, Koh PW, Deng T, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Ng SC, Fernhoff NB, George BM, Wernig G, Salomon RAE, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT†, Weissman IL† (2016). Cell 166: 451-67.

See also: mesoderm RNA-seq online portal 

An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development

Koh PW*, Sinha R*, Barkal AA, Morganti RM, Chen A, Weissman IL†, Ang LT†, Kundaje A†, Loh KM† (2016). Scientific Data 3: 160109.

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations

Loh KM*, Ang LT*, Zhang J**, Kumar V**, Ang J, Auyeong JQ, Lee KL, Choo SH, Lim CYY, Nichane M, Tan J, Noghabi MS, Azzola L, Ng ES, Durruthy-Durruthy J, Sebastiano V, Poellinger L, Elefanty AG, Stanley EG, Chen Q, Prabhakar S, Weissman IL, Lim B (2014). Cell Stem Cell 14: 237-52.

Protocol for efficient generation of human artery and vein endothelial cells from pluripotent stem cells

Loh KM†, Zheng SL†, Liu KJ, Yin Q, Amir-Ugokwe ZA, Jha SK, Qi Y, Wazny VK, Nguyen AT, Chen A, Cheung C, Spiekerkoetter E, Red-Horse K, Ang LT† (2024). STAR Protocols 6: 103494.

Dopaminergic neurons entering the brain under the immunological cover of darkness

Chai T*, Chen JY*, Loh KM (2025). Cell Stem Cell 32: 675-677.  

Can developmental signals shatter or mend our genomes?

Qu Y & Loh KM (2024). Trends in Genetics, advance online publication.

Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development

Loh KM & Ang LT (2024). Seminars in Cell and Developmental Biology 155(Pt C):62-75.

Bridging naïve and primed pluripotency

Dundes CD & Loh KM (2020). Nature Cell Biology 22: 513-515.

Obliterating obstacles to an odyssey

Nichane M, Loh KM (2018). Cell Stem Cell 23: 313-15.

Generating spatial form and cellular diversity: Wnt signaling and the evolution of multicellular animals

Loh KM*, van Amerongen R*, Nusse R (2016). Developmental Cell 38: 643-655.

Equilibrium established

Loh KM and Lim B (2015). Nature 521: 299-300.

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

Clevers H, Loh KM, Nusse R (2014). Science 346: 1248012.

Rejuvenating Tithonus

Loh KM and Lim B (2013). EMBO Reports 14: 583-4.

Actors in the cell reprogramming drama

Loh KM and Lim B (2012). Nature 488: 599-600.

Recreating pluripotency?

Loh KM and Lim B (2010). Cell Stem Cell 7: 137-9.